Interaction of human DNA topoisomerase I with G-quartet structures.

  title={Interaction of human DNA topoisomerase I with G-quartet structures.},
  author={Paola B. Arimondo and Jean François Riou and Jean-Louis Mergny and Jamal Tazi and J S Sun and Th{\'e}r{\`e}se Garestier and Claude H{\'e}l{\`e}ne},
  journal={Nucleic acids research},
  volume={28 24},
Because of their role in the control of the topological state of DNA, topoisomerases are ubiquitous and vital enzymes, which participate in nearly all events related to DNA metabolism including replication and transcription. We show here that human topoisomerase I (Topo I) plays an unexpected role of 'molecular matchmaker' for G-quartet formation. G-quadruplexes are multi-stranded structures held together by square planes of four guanines ('G-quartets') interacting by forming Hoogsteen hydrogen… CONTINUE READING

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