Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.

@article{Welch1998InteractionOH,
  title={Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation.},
  author={Matthew D Welch and Jody Rosenblatt and Justin Skoble and Daniel A Portnoy and Timothy J Mitchison},
  journal={Science},
  year={1998},
  volume={281 5373},
  pages={105-8}
}
Actin filament assembly at the cell surface of the pathogenic bacterium Listeria monocytogenes requires the bacterial ActA surface protein and the host cell Arp2/3 complex. Purified Arp2/3 complex accelerated the nucleation of actin polymerization in vitro, but pure ActA had no effect. However, when combined, the Arp2/3 complex and ActA synergistically stimulated the nucleation of actin filaments. This mechanism of activating the host Arp2/3 complex at the L. monocytogenes surface may be… CONTINUE READING
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