Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity.

@article{Tsutsumi2002InteractionOH,
  title={Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity.},
  author={Takeya Tsutsumi and Tetsuro Suzuki and Takashi Shimoike and Ryosuke Suzuki and Kyoji Moriya and Yoshizumi Shintani and Hajime Fujie and Yoshiharu Matsuura and Kazuhiko Koike and Tatsuo Miyamura},
  journal={Hepatology},
  year={2002},
  volume={35 4},
  pages={
          937-46
        }
}
Hepatic steatosis and hepatocellular carcinoma (HCC) are common and serious features of hepatitis C virus (HCV) infection, and the core protein has been shown to play distinct roles in the pathogenesis. Here we report the direct interaction of HCV core protein with retinoid X receptor alpha (RXRalpha), a transcriptional regulator that controls many aspects of cell proliferation, differentiation, and lipid metabolism. The core protein binds to the DNA-binding domain of RXRalpha, leading to… CONTINUE READING
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