Interaction of haemodynamic and metabolic pathways in the genesis of diabetic nephropathy.

@article{Leon2005InteractionOH,
  title={Interaction of haemodynamic and metabolic pathways in the genesis of diabetic nephropathy.},
  author={Carlos A Tache Leon and Leopoldo Raij},
  journal={Journal of hypertension},
  year={2005},
  volume={23 11},
  pages={1931-7}
}
Clinical diabetic nephropathy is characterized by an earlier functional phase in which hyperglycaemia is accompanied by an increased glomerular filtration rate and microalbuminuria; the persistence of this high-flow and high-pressure state, added to a poor control of hyperglycaemia, fosters renal damage and proteinuria, accompanied by a decline in glomerular filtration rate and progression to end-stage renal disease. In this review, we present glucose transporter 1 (GLUT-1) as a novel link that… CONTINUE READING
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