Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype

@inproceedings{Liang2017InteractionOG,
  title={Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype},
  author={Yuh-Jin Liang and Chen-Yu Wang and I-An Wang and Yi-Wen Chen and Li-tzu Li and Chuang-yu Lin and Ming-Yi Ho and Tsung-Lung Chou and Ya-Hui Wang and Shih-Pin Chiou and Yu-Ju Lin and John Yu},
  booktitle={Oncotarget},
  year={2017}
}
Many studies have suggested that disialogangliosides, GD2 and GD3, are involved in the development of various tumor types. However, the functional relationships between ganglioside expression and cancer development or aggressiveness are not fully described. GD3 is upregulated in approximately half of all invasive ductal breast carcinoma cases, and enhanced expression of GD3 synthase (GD3S, alpha-N-acetylneuraminide alpha-2,8-sialyltransferase) in estrogen receptor-negative breast tumors, was… CONTINUE READING