Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy.

  title={Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy.},
  author={Cong Lei and Xiaolin Niu and Jin Da Wei and Jianhong Zhu and Yi Zhu},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={399 1-2},
BACKGROUND Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown etiology. We studied the gene-environment interaction in the pathogenesis of KD by assessing the association of low blood selenium and polymorphisms in glutathione peroxidase-1 (GPx-1) gene. METHODS The concentration of blood selenium and the activity and polymorphisms of GPx-1 in 71KD patients and 290 controls were measured. The functions of rat neonatal cardiomyocytes resulting from overexpression of 2 variants of… CONTINUE READING


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