Interaction of glutamine and arginine on cerebrovascular reactivity to hypercapnia.

@article{Okada2000InteractionOG,
  title={Interaction of glutamine and arginine on cerebrovascular reactivity to hypercapnia.},
  author={Tsuyoshi Okada and Yoshimasa Watanabe and SaulW. Brusilow and RichardJ. Traystman and Raymond C Koehler},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 5},
  pages={
          H1577-84
        }
}
Glutamine is purported to inhibit recycling of citrulline to arginine and to limit nitric oxide release in vitro. However, vasoactive effects of glutamine have not been clearly demonstrated in vivo. During hyperammonemia, impaired cerebrovascular reactivity to CO(2) is related to glutamine accumulation. We tested the hypotheses that 1) glutamine infusion in the absence of hyperammonemia impairs cerebrovascular CO(2) reactivity and 2) arginine infusion preserves CO(2) reactivity during glutamine… CONTINUE READING

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