Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog.

@article{Gustavson2003InteractionOG,
  title={Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog.},
  author={Stephanie M. Gustavson and Chang An Chu and Makoto Nishizawa and Ben Farmer and Doss W. Neal and Ying Yang and E. Patrick Donahue and Paul J. Flakoll and Alan D. Cherrington},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={284 4},
  pages={E695-707}
}
Epinephrine increases net hepatic glucose output (NHGO) mainly via increased gluconeogenesis, whereas glucagon increases NHGO mainly via increased glycogenolysis. The aim of the present study was to determine how the two hormones interact in controlling glucose production. In 18-h-fasted conscious dogs, a pancreatic clamp initially fixed insulin and glucagon at basal levels, following which one of four protocols was instituted. In G + E, glucagon (1.5 ng x kg(-1) x min(-1); portally) and… CONTINUE READING

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