Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance.

@article{Kwatra2010InteractionOG,
  title={Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance.},
  author={Deep Kwatra and Ramya Krishna Vadlapatla and Aswani Dutt Vadlapudi and Dhananjay Pal and Ashim K Mitra},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={395 1-2},
  pages={114-21}
}
The purpose of the study is to screen the interactions of fourth generation fluoroquinolone-gatifloxacin with efflux pumps, i.e., P-gp, MRP2 and BCRP. Mechanism of gatifloxacin interaction with efflux transporters may explain its acquired resistance. Such clarification may lead to the development of strategies to overcome efflux and enhance its bioavailability at target site. This process will aid in the reduction of dose volume, further eliminating the chances of systemic toxicity from topical… CONTINUE READING