Interaction of fosfomycin with the glycerol 3-phosphate transporter of Escherichia coli.

@article{Santoro2011InteractionOF,
  title={Interaction of fosfomycin with the glycerol 3-phosphate transporter of Escherichia coli.},
  author={Antonella Santoro and Anna Rita Cappello and Marianna Madeo and Emanuela Martello and Domenico Iacopetta and Vincenza Dolce},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1810 12},
  pages={1323-9}
}
BACKGROUND Fosfomycin is widely used to treat urinary tract and pediatric gastrointestinal infections of bacteria. It is supposed that this antibiotic enters cells via two transport systems, including the bacterial Glycerol-3-phosphate Transporter (GlpT). Impaired function of GlpT is one mechanism for fosfomycin resistance. METHODS The interaction of fosfomycin with the recombinant and purified GlpT of Escherichia coli reconstituted in liposomes has been studied. IC(50) and the half… CONTINUE READING