Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site.

@article{Hui2000InteractionOF,
  title={Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site.},
  author={Kwok Min Hui and Xi Han Wang and Hong H Xue},
  journal={Planta medica},
  year={2000},
  volume={66 1},
  pages={91-3}
}
A radioreceptor binding assay was used to guide the isolation of four chemical constituents in the organic solvent extracts of Scutellaria baicalensis Georgi capable of binding to the benzodiazepine site (BZD-S) of the GABAA receptor: wogonin (Ki = 2.03 +/- 0.24 microM), baicalin (Ki = 77.10 +/- 4.79 microM), baicalein (Ki = 5.69 +/- 0.95 microM), and scutellarein (Ki = 12.00 +/- 1.27 microM). All four compounds contain the flavonoid phenylbenzopyrone nucleus. Based on BZD-S binding, the order… CONTINUE READING

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