• Corpus ID: 7389244

Interaction of ethanol with amylobarbitone, phenobarbitone and methaqualone.

@article{Tilstone1978InteractionOE,
  title={Interaction of ethanol with amylobarbitone, phenobarbitone and methaqualone.},
  author={William J. Tilstone and P. C. Reavey},
  journal={Research communications in chemical pathology and pharmacology},
  year={1978},
  volume={19 2},
  pages={
          233-42
        }
}
  • W. Tilstone, P. Reavey
  • Published 1978
  • Medicine
  • Research communications in chemical pathology and pharmacology
The presence and mechanism of synergism of action between ethanol and amylobarbitone, phenobarbitone or methaqualone was determined by application of simple pharmacokinetic models to log dose-response curves and plasma concentration-time curves for the hypnotics alone or when ethanol was given concurrently. For all three hypnotics, ethanol was found to increase the duration of hypnosis, but the mechanism of action was different for each. A sub-hypnotic dose of ethanol increased the volume of… 
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