• Corpus ID: 7389244

Interaction of ethanol with amylobarbitone, phenobarbitone and methaqualone.

  title={Interaction of ethanol with amylobarbitone, phenobarbitone and methaqualone.},
  author={William J. Tilstone and P. C. Reavey},
  journal={Research communications in chemical pathology and pharmacology},
  volume={19 2},
  • W. Tilstone, P. Reavey
  • Published 1978
  • Medicine
  • Research communications in chemical pathology and pharmacology
The presence and mechanism of synergism of action between ethanol and amylobarbitone, phenobarbitone or methaqualone was determined by application of simple pharmacokinetic models to log dose-response curves and plasma concentration-time curves for the hypnotics alone or when ethanol was given concurrently. For all three hypnotics, ethanol was found to increase the duration of hypnosis, but the mechanism of action was different for each. A sub-hypnotic dose of ethanol increased the volume of… 
2 Citations
Interaction between Ethanol and Opioids in a Protozoan Assay
A non-specific interaction between ethanol and opioids may also take place in vivo, which could cause increased toxicity over and above the involvement of opioid receptors, information from this study should aid understanding of the mechanism of interactions in human poisoning by agents with membrane stabilizing activity.
Thermodynamic Interpretation of Synergism in Barbiturate/ Ethanol Poisoning
  • L. King
  • Chemistry, Medicine
    Human toxicology
  • 1985
Ethanol and barbiturate drugs behave as non-specific depressants of the central nervous system (Ferguson substances). Their interaction can therefore be understood quantitatively by the application