Interaction of ethanol with β‐carotene: Delayed blood clearance and enhanced hepatotoxicity

@article{Leo1992InteractionOE,
  title={Interaction of ethanol with $\beta$‐carotene: Delayed blood clearance and enhanced hepatotoxicity},
  author={Maria Anna Leo and C. I. Kim and N Lowe and Charles S. Lieber},
  journal={Hepatology},
  year={1992},
  volume={15}
}
Because we had found that ethanol interacts with retinol, we investigated whether it also affects its precursor, β‐carotene. In 14 baboons fed ethanol (50% of total energy) for 2 to 5 yr with a standard amount of β‐carotene (one 200‐gm carrot/day), levels of β‐carotene were much higher than in controls fed isocaloric carbohydrate, both in plasma (122.5 ± 30.9 nmol/dl vs. 6.3 ± 1.4 nmol/dl; p < 0.005) and in liver (7.9 ± 1.1 nmol/gm vs. 1.8 ± 0.5 nmol/gm; p < 0.001). Even 20 days after… 
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References

SHOWING 1-10 OF 48 REFERENCES
Kinetic Characteristics of β-Carotene Uptake and Depletion in Rat Tissue
TLDR
The absence of BC in fat suggests that BC distribution is not simply a matter of deposition into lipid depots, and there was a wide range in tissue levels of BC; liver had the greatest value with 50 micrograms/g tissue, and muscle had the lowest value.
Attenuation of alcohol‐induced hepatic fibrosis by polyunsaturated lecithin
TLDR
Results indicate that some component of lecithin exerts a protective action against the fibrogenic effects of ethanol, and that the polyunsaturated phospholipids themselves might be responsible for the protective effect.
Biological actions of carotenoids 1
  • A. Bendich, J. Olson
  • Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1989
TLDR
In epidemiological studies, the intake of carotenoid‐rich fruits and vegetables has been correlated with protection from some forms of cancer, particularly lung cancer, and serum β‐carotene levels have been associated with a decreased chance of developing lung cancer.
Provitamin A Function of Carotenoids: The Conversion of β-Carotene into Vitamin A
TLDR
To remain viable as an alternative pathway of vitamin A formation from carotenoids in mammals, the excentric cleavage hypothesis clearly requires unambiguous direct supporting evidence.
Beta-carotene and cancer prevention: the Basel Study.
TLDR
Low plasma carotene which is known to reflect carotenes intake is in the Basel Study associated with increased cancer risk.
The influence of vitamin a on the susceptibility of the rat lung to 3‐methylcholanthrene
The susceptibility of rats to pulmonary carcinogens is increased in the absence of vitamin A intake even when considerable amounts (0.4 nmole/mg) of vitamin A are stored in the liver and deficiency
The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine.
  • J. Olson, O. Hayaishi
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1965
TLDR
In the present report an enzyme has been found in the supernatant solution of rat liver and intestine which converts 13-carotene into retinal and retinol as its sole products.
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