Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo.

@article{Grant1992InteractionOE,
  title={Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo.},
  author={Derrick S. Grant and James L. Kinsella and Rafael Fridman and Robert D. Auerbach and B A Piasecki and Yoshihiko Yamada and Mona Zain and Hynda K. Kleinman},
  journal={Journal of cellular physiology},
  year={1992},
  volume={153 3},
  pages={614-25}
}
Endothelial cells are known to bind to laminin, and two peptides derived from the laminin A (CTFALRGDNP) and B1 (CDPGYIGSR) chains block the capillary-like tube formation on a laminin-rich basement membrane matrix, Matrigel. In the present study, we have used various in vitro and in vivo assays to investigate the angiogenic-biologic effects of a third active site in the laminin A chain, CSRARKQAASIKVAVSADR (designated PA22-2) on endothelial cells. The SIKVAV-containing peptide was as active as… CONTINUE READING