Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration.

@article{Tomkowicz2007InteractionOE,
  title={Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration.},
  author={Brian E. Tomkowicz and Katherine A Rybinski and Brian Foley and Wolfgang Ebel and Brad Kline and Eric L. Routhier and Philip M. Sass and Nicholas C. Nicolaides and Luigi Grasso and Yuhong Zhou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 46},
  pages={17965-70}
}
Endosialin/TEM1 was originally discovered as a human embryonic fibroblast-specific antigen and was later found to be differentially expressed in tumor stroma and endothelium. Endosialin/TEM1 overexpression has been observed in many cancers of various tissue origin, including colon, breast, pancreatic, and lung. The knockout (KO) mouse model showed the absence of endosialin/TEM1 expression reduced growth, invasion, and metastasis of human tumor xenografts. In addition, lack of endosialin/TEM1… CONTINUE READING

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