Interaction of endogenous endothelin-1 and inhaled nitric oxide in term and preterm infants.

@article{Truog2002InteractionOE,
  title={Interaction of endogenous endothelin-1 and inhaled nitric oxide in term and preterm infants.},
  author={William E. Truog and Eugenia K Pallotto and Perry L Clark and Beverly A. Banks and Harold A Kaftan and Ikechukwu I. Ekekezie and Mike Norberg and Roberta A. Ballard},
  journal={Clinical science},
  year={2002},
  volume={103 Suppl 48},
  pages={294S-297S}
}
The peptide endothelin-1 (ET-1) plays an unknown role in the pathogenesis and progression of two important neonatal pulmonary disorders, chronic lung disease (CLD) of prematurity and persistent pulmonary hypertension of the newborn (PPHN). Inhaled nitric oxide (INO) is a proven vasodilator therapy in PPHN and is an experimental therapy in CLD. We sought to determine the effects, if any, of the interaction of inhaled INO with ET-1 in these two separate disorders. Infants (n=21) with PPHN (mean… CONTINUE READING

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