Interaction of dopamine system genes and cognitive functions in patients with schizophrenia and their relatives and in healthy subjects from the general population

@article{Alfimova2007InteractionOD,
  title={Interaction of dopamine system genes and cognitive functions in patients with schizophrenia and their relatives and in healthy subjects from the general population},
  author={Margarita V Alfimova and V E Golimbet and I. K. Gritsenko and T V Lezheiko and L I Abramova and M A Strel'tsova and I. V. Khlopina and Richard P. Ebstein},
  journal={Neuroscience and Behavioral Physiology},
  year={2007},
  volume={37},
  pages={643-650}
}
Linkage between the DRD4 and COMT genes and cognitive measures characterizing verbal memory, executive functions, and associative processes was studied in 150 patients with schizophrenia, 83 of their relatives, and 118 mentally healthy subjects without any family history of psychoses, with the aim of detecting the main effects of the polymorphic markers −809G/A and −521C/T (DRD4) and Val158Met (COMT) when present individually and together. The group of patients showed a main effect for… Expand
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