Interaction of dopamine system genes and cognitive functions in patients with schizophrenia and their relatives and in healthy subjects from the general population

  title={Interaction of dopamine system genes and cognitive functions in patients with schizophrenia and their relatives and in healthy subjects from the general population},
  author={Margarita V. Alfimova and V. E. Golimbet and I. K. Gritsenko and T V Lezheiko and L I Abramova and M A Strel'tsova and I. V. Khlopina and Richard P. Ebstein},
  journal={Neuroscience and Behavioral Physiology},
Linkage between the DRD4 and COMT genes and cognitive measures characterizing verbal memory, executive functions, and associative processes was studied in 150 patients with schizophrenia, 83 of their relatives, and 118 mentally healthy subjects without any family history of psychoses, with the aim of detecting the main effects of the polymorphic markers −809G/A and −521C/T (DRD4) and Val158Met (COMT) when present individually and together. The group of patients showed a main effect for… 

Influence of dopaminergic and serotoninergic genes on working memory in healthy subjects.

The results obtained in the study indicate that dopaminergic and serotoninergic genes may play a role in modulating the executive function and working memory processes in healthy subjects.

Dopaminergic genes polymorphisms and prefrontal cortex efficiency among obese people - whether gender is a differentiating factor?

Data analysis indicates different dependences of the prefrontal cortex function, in the study group, from different elements such as genetic factors, metabolic aspects of obesity, and hormonal activity (estrogen).

Schizophrenia: genetics, prevention and rehabilitation

The joint effect of genetic and environmental factors on liability to schizophrenia and relationships between genes and cognitive endophenotypes are investigated to indicate a pivotal role of psychiatric genetics in prevention and rehabilitation of schizophrenic psychoses.

Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort.

The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users

Based on the impaired clustering and switching strategies observed in ecstasy users, it might be proposed that both semantic knowledge and retrieval are impaired in this population.

A influência genética sobre a memória humana: uma revisão

A systematic review was done, including papers that investigated the association among genetic variants and memory scores, and results of all papers found in the PubMed database since 2000 were included.

Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders

For this first MPH pharmacogenetic study in children with ASD, multiple monoaminergic gene variants may help explain individual differences in MPH’s efficacy and tolerability.

Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors

Tolcapone enhanced neurocognition and engaged electroencephalogram measures relevant to cognitive processes in specific subgroups of healthy individuals and provides a strong basis for future biomarker-informed procognitive studies in schizophrenia patients.

Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics.

The salient features of tardive dyskinesia etiopathology, current status of TD genetics, interactions between genetic and nongenetic factors, some major drawbacks, challenges and expected focus in TD research over the next decade are discussed, with emphasis on pharmacogenetics.



Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

The data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia.

Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.

Evaluated patients with schizophrenia with acute untreated schizophrenia suggest that a genetically determined variation in prefrontal dopamine catabolism impacts the therapeutic profile of olanzapine.

COMT Gene Polymorphism Is Associated with Declarative Memory in Adulthood and Old Age

Division of episodic memory into its recall and recognition components showed that the difference was specific to episodic recall, not recognition tasks; an effect that was observed across three age groups (middle-age, young-old, and old-old adults) and over a 5-year period.

Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia.

The findings provide convergent evidence that an intermediate phenotype related to prefrontal cortical function represents a viable approach to understanding neuropsychiatric disorders with complex genetic etiologies and individual differences in cognition.

New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis.

The results seem to confirm the role of COMT genotype in the modulation of executive functions related to frontal lobe function in healthy individuals but not in schizophrenia patients.

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.

These data are consistent with those of previous studies, suggesting that a functional genetic polymorphism may influence prefrontal cognition.

Genetic and neurochemical modulation of prefrontal cognitive functions in children.

The authors achieved a level of specificity never previously attempted; the COMT polymorphism was found to be differentially related to performance on tasks linked to the same prefrontal region by whether cognitive requirements of the tasks were sensitive to the level of dopamine found.

Neurocognitive correlates of the COMT Val158Met polymorphism in chronic schizophrenia

Catechol-O-Methyltransferase (COMT) Val108/158 Met polymorphism does not modulate executive function in children with ADHD

Contrary to the observed association between WCST performance and the Val108/158Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD.

DRD4 gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): Effects of associated alleles at the VNTR and −521 SNP

The results suggest dissociable effects of the “associated alleles” of DRD4 gene variants on sustained attention: while the 7‐repeat allele of the VNTR is associated with relatively better performance, the A allered of the −521 SNP isassociated with poorer performance.