Interaction of diuron and related substituted phenylureas with the Ah receptor pathway.

@article{Zhao2006InteractionOD,
  title={Interaction of diuron and related substituted phenylureas with the Ah receptor pathway.},
  author={Bin Zhao and David S Baston and Bruce B Hammock and Michael S. Denison},
  journal={Journal of biochemical and molecular toxicology},
  year={2006},
  volume={20 3},
  pages={103-13}
}
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of structurally diverse chemicals, including the ubiquitous environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Here, we have examined the ability of diuron, a widely used herbicide, and several structurally related substituted phenylureas to bind to and activate/inhibit the AhR and AhR signal transduction. Diuron induced CYP1A1 mRNA levels in… CONTINUE READING