Interaction of digitonin and its analogs with membrane cholesterol.

  title={Interaction of digitonin and its analogs with membrane cholesterol.},
  author={Mai Nishikawa and Satoshi Nojima and Toshihiko Akiyama and Ushio Sankawa and Keizo Inoue},
  journal={Journal of biochemistry},
  volume={96 4},
The interaction of digitonin with membrane cholesterol was studied by using various digitonin analogs, and radioactive desglucodigitonin. The following results were obtained concerning the effect of digitonin on erythrocytes, granulocytes and liposomes. Digitonin and its analogs showed activity to induce hemolysis, granulocyte activation and liposomal membrane damage. The activity was affected by change of the carbohydrate residue of the molecule; the order of hemolytic activity was digitonin… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…