Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.

@article{Jaggar1993InteractionOD,
  title={Interaction of diazoxide and cromakalim with ATP-regulated K+ channels in rodent and clonal insulin-secreting cells.},
  author={Jonathan H Jaggar and Elizabeth A. Harding and B J Ayton and Mark J. Dunne},
  journal={Journal of molecular endocrinology},
  year={1993},
  volume={10 1},
  pages={59-70}
}
The hyperglycaemia-inducing sulphonamide diazoxide has been previously shown to mediate its effects upon insulin secretion by opening K+ channels and hyperpolarizing the beta-cell membrane. The target site has been characterized as the ATP-regulated K+ (K+ATP) channel protein. In the present study, a detailed investigation of interactions of diazoxide and… CONTINUE READING