Interaction of deoxyguanosine nucleotide analogs with human telomerase.

  title={Interaction of deoxyguanosine nucleotide analogs with human telomerase.},
  author={Susan W Tendian and William B. Parker},
  journal={Molecular pharmacology},
  volume={57 4},
To maintain the telomeres at the ends of the chromosomes, telomerase in human cells adds a repeating sequence of nucleotides (TTAGGG) to the 3'-end of each chromosome using an RNA component of the enzyme as the template for DNA synthesis. Because of the selective expression of this enzyme in cancer cells, we have evaluated the interaction of human telomerase with several deoxyguanosine nucleotides of clinical importance. 2',3'-dideoxyguanosine 5'-triphosphate, 6-thio-2'-deoxyguanosine 5… CONTINUE READING
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