Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.

@article{Zhang2011InteractionOC,
  title={Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.},
  author={Xuemei Zhang and Rong Zhong and Zhi Zhang and Juxiang Yuan and Li Liu and Yanli Wang and Susan Kadlubar and Fumin Feng and Xiaoping Miao},
  journal={Molecular carcinogenesis},
  year={2011},
  volume={50 11},
  pages={876-83}
}
Overexpression of cyclooxygenase (COX)-2 has been implicated in the development of cancer. This study aimed to evaluate the relationship between genetic variants in COX-2 promoter interacting with Helicobacter pylori and the susceptibility to gastric cancer (GC). Three COX-2 polymorphisms -1290A>G (rs689465), -1195G>A (rs689466), and -765G>C (rs20417) were genotyped in 323 GC patients and 944 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression… CONTINUE READING

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