Interaction of cyclic AMP modulating agents with levcromakalim in the relaxation of rat isolated mesenteric artery.

@article{Omar2000InteractionOC,
  title={Interaction of cyclic AMP modulating agents with levcromakalim in the relaxation of rat isolated mesenteric artery.},
  author={Rahmat Omar and F E Bottrill and C. Robin Hiley and Richard White},
  journal={European journal of pharmacology},
  year={2000},
  volume={401 1},
  pages={
          85-96
        }
}
The effect of cyclic AMP modulating agents on levcromakalim-induced relaxation was investigated in myograph-mounted rat mesenteric arteries. Forskolin (adenylyl cyclase activator), dibutyryl cyclic AMP (protein kinase A activator) and 5'-N-ethylcarboxamidoadenosine (NECA; adenosine receptor agonist) all potentiated the vasorelaxant effects of levcromakalim. The modulatory and relaxant effects of dibutyryl cyclic AMP, NECA and forskolin were sensitive to the protein kinase A inhibitor, Rp-cAMPS… CONTINUE READING