Interaction of corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo.

@article{Rivier1983InteractionOC,
  title={Interaction of corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo.},
  author={Catherine Rivier and Wylie W. Vale},
  journal={Endocrinology},
  year={1983},
  volume={113 3},
  pages={939-42}
}
A possible interaction between synthetic ovine corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) was tested in anesthetized and in freely moving rats. In animals whose endogenous CRF release was blocked by chlorpromazine-morphine-nembutal, AVP elicited a significantly lower maximum ACTH response than did CRF, whereas the concomitant injection of both peptides resulted in a marked potentiation of CRF-induced ACTH secretion. In freely moving rats, AVP was more potent than CRF… CONTINUE READING
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