Interaction of colchicine with human serum albumin investigated by spectroscopic methods.

@article{Hu2005InteractionOC,
  title={Interaction of colchicine with human serum albumin investigated by spectroscopic methods.},
  author={Yan-Jun Hu and Yi Liu and Ru-Ming Zhao and Song-sheng Qu},
  journal={International journal of biological macromolecules},
  year={2005},
  volume={37 3},
  pages={122-6}
}
We investigated the interaction between colchicine and human serum albumin (HSA) by fluorescence and UV-vis absorption spectroscopy. In the mechanism discussion, it was proved that the fluorescence quenching of HSA by colchicine is a result of the formation of colchicines-HSA complex; van der Waals interactions and hydrogen bonds play a major role in stabilizing the complex. The modified Stern-Volmer quenching constant K(a) and corresponding thermodynamic parameters deltaH, deltaG, deltaS at… CONTINUE READING

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