Interaction of clozapine and ciprofloxacin: a case report

  title={Interaction of clozapine and ciprofloxacin: a case report},
  author={Rajvinder Singh Sambhi and Ramneesh Puri and Gaynor Cynan Jones},
  journal={European Journal of Clinical Pharmacology},
Dear Editor We report a case of similar pharmacokinetic interaction between ciprofloxacin and clozapine, as demonstrated by Raaska et al., but to a much higher degree (i.e. a 500% increase in clozapine levels). Presentation: A 47-year-old man has been an inpatient in a medium-security forensic psychiatry unit with a diagnosis of treatment-resistant paranoid schizophrenia. He was being treated with clozapine 750 mg, amisulpride 450 mg and lorazepam 4.5 mg daily. He started complaining of pain in… CONTINUE READING

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