Interaction of cisplatin and noise on the peripheral auditory system

@article{Gratton1990InteractionOC,
  title={Interaction of cisplatin and noise on the peripheral auditory system},
  author={Michael Anne Gratton and Richard J. Salvi and Barton A. Kamen and Samuel S. Saunders},
  journal={Hearing Research},
  year={1990},
  volume={50},
  pages={211-223}
}
Synergistic Ototoxicity of Noise and Chemical Ototoxins
TLDR
Exposure to certain organic solvents, or cationic drugs, such as aminoglycoside antibiotics, can induce permanent hearing loss and simultaneous exposure to chemical ototoxins and noise potentiates auditory dysfunction that is greater than the sum of each insult given individually.
Long-Term Synergistic Interaction of Cisplatin- and Noise-Induced Hearing Losses
TLDR
It is suggested that the cisplatin induced cochlear injuries that were not severe enough to result in threshold shift, but left the cochlea in a state of heightened susceptibility to future injury.
Potentiation of Chemical Ototoxicity by Noise.
TLDR
Moderate noise levels potentiate both aminoglycoside- and cisplatin-induced ototoxicity in both rate of onset and in severity of auditory dysfunction, suggesting that simultaneous exposure to chemical ototoxins and moderate levels of noise can potentiate auditory dysfunction.
Comparison of Cochlear Cell Death Caused by Cisplatin, Alone and in Combination with Furosemide
TLDR
The combined regimen resulted in comparable hearing loss and hair cell loss but a markedly lower mortality, and failed to cause similar damage to spiral ganglion neurons (SGN), which suggests that the combined regimen did not mimic the damage to cochlear neuronal innervation caused by the clinical application of cisplatin.
Effects of noise and salicylate on hair cell loss in the chinchilla cochlea.
Chinchillas were exposed to octave band noise, sodium salicylate (300 mg/kg per day intraperitoneally), or the combination of both agents for 15 days. The octave band noise exposure was centered at
Cochlear Cell Death Induced Via Cisplatin or Gentamycin in Combination with Furosemide in Rodents
TLDR
Overall, the methods of co-administration of cisplatin/gentacimin and furosemide in rodents facilitate ototoxic model build.
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References

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Cis-platin ototoxicity in previously noise-exposed guinea pigs.
TLDR
Regular audiometric control before and during Cis-platin treatment is supported for easy detection of incipient hearing loss, before the speech frequency range is affected.
Potentiating effects of cisplatin and ethacrynic acid in ototoxicity.
TLDR
The ototoxic interaction seemingly has a greater effect on the hair cells than on the stria vascularis and Baseline and periodic audiometry should be performed when both of these drugs are administered clinically.
Early detection of cisplatin ototoxicity selected case reports
TLDR
A recently developed high frequency auditory measurement technique was applied to a sample of patients receiving cisplatin, revealing a high incidence of nonreversible cochlear toxicity with a predilection for involvement of the higher frequencies.
Ototoxic and Nephrotoxic Effects of Combined Treatment with cis-Diamminedichloroplatinum and Kanamycin in the Guinea Pig
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  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
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TLDR
Combined treatment with CSP and kanamycin produced the most significant cortical medullary tubular necrosis and interstitial nephritis and for the first time localization of platinum in the inner ear is reported.
Combined effects of noise and neomycin. Cochlear changes in the guinea pig.
TLDR
A marked interaction leading to augmentation of damage was found when neomycin was combined with 115 dB noise (Group I), and losses in cochlear sensitivity, averaged across all frequencies, amounted to 62 dB in Group I, whereas the averaged losses for Groups II and III were only 16 dB and 17 dB respectively.
Auditory toxicity effects of long‐term cis‐dichlorodiammineplatinum II therapy in genitourinary cancer patients
TLDR
Individual variability in susceptibility to and recovery from ototoxicity necessitates systematic audiometric monitoring throughout the therapy, and pure tone threshold levels deteriorated across time particularly by the 52nd week and at the higher frequencies.
Comparison of auditory-evoked potentials and behavioral thresholds in the normal and noise-exposed chinchilla.
TLDR
The two independent assessments of auditory sensitivity showed good agreement and the results support the use of AEP testing in experimental animals.
cis-Platinum ototoxicity.
TLDR
Audiographic evaluation appears necessary for monitoring the treatment of cancer patients with cis-platinum and high drug dosages caused larger threshold elevations and extended to lower frequencies.
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