Interaction of cimetidine and histamine with superoxide generated in a cell-free system and in neutrophils

Abstract

We investigated the influence of CIM and HIS on the SUP and CH in the SUP generating cell-free xanthine oxidase system and in human neutrophils. As measured by CCR or CH, we found that HIS inhibited SUP output in both systems. The HIS concentration required for a measurable inhibition was somewhat higher in the xanthine oxidase system than in neutrophils… (More)
DOI: 10.1007/BF02074703

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