Interaction of chromatin-associated Plk1 and Mcm7.

@article{Tsvetkov2005InteractionOC,
  title={Interaction of chromatin-associated Plk1 and Mcm7.},
  author={Lyuben M. Tsvetkov and David F. Stern},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 12},
  pages={11943-7}
}
Plk1 is a multifunctional protein kinase involved in regulation of mitotic entry, chromosome segregation, centrosome maturation, and mitotic exit. Plk1 is a target of DNA damage checkpoints and aids resumption of the cell cycle during recovery from G2 arrest. The polo-box domain (PBD) of Plk1 interacts with phosphoproteins and localizes Plk1 to some mitotic structures. In a search for proteins that interact with the PBD of Plk1, we identified two of the minichromosome maintenance (MCM) proteins… CONTINUE READING

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