Interaction of certain metal ions with aryl hydrocarbon hydroxylase of rat lung microsomes.

Abstract

The effect of varying concentrations of cadmium, copper, zinc, and selenite on the activity of aryl hydrocarbon hydroxylase (AHH) of rat lungs was studied in vitro. All the metals resulted in a strong inhibition of enzyme activity. Copper and zinc were more inhibitory to rat lung AHH than cadmium and selenite. There was an additive inhibition of AHH… (More)

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