Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells.

Abstract

Autophagy plays a pivotal role in cellular homeostasis and adaptation to adverse environments, although the regulation of this process remains incompletely understood. We have recently observed that caveolin-1 (Cav-1), a major constituent of lipid rafts on plasma membrane, can regulate autophagy in cigarette smoking-induced injury of lung epithelium… (More)
DOI: 10.1152/ajplung.00268.2013

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