Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells.

@article{Pires1999InteractionOC,
  title={Interaction of cationic liposomes and their DNA complexes with monocytic leukemia cells.},
  author={Pedro Pires and S{\'e}rgio Sim{\~o}es and Shlomo Nir and Rezső G{\'a}sp{\'a}r and Nejat D{\"u}zg{\"u}neş and Maria Conceiç{\~a}o Pedroso de Lima},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1418 1},
  pages={71-84}
}
Cationic liposomes complexed with DNA have been used extensively as non-viral vectors for the intracellular delivery of reporter or therapeutic genes in culture and in vivo. We examined the relationship between the characteristics of the lipoplexes, their mode of interaction with monocytic THP-1 cells and their ability to transfect these cells. We determined the size and zeta potential of cationic liposomes (composed of 1,2-dioleoyl-3-(trimethylammonium) propane (DOTAP) and its mixtures with… CONTINUE READING

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