Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters.

@article{Liang2009InteractionOC,
  title={Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters.},
  author={Ying-Jian Liang and Juan Zhen and Nianhang Chen and Maarten E. A. Reith},
  journal={Journal of neurochemistry},
  year={2009},
  volume={109 4},
  pages={981-94}
}
Our previous work suggested that collapsing the Na(+) gradient and membrane potential converts the dopamine (DA) transporter (DAT) to an inward-facing conformation with a different substrate binding profile. Here, DAT expressing human embryonic kidney 293 cells were permeabilized with digitonin, disrupting ion/voltage gradients and allowing passage of DAT substrates. The potency of p-tyramine and other non-catechols (d-amphetamine, beta-phenethylamine, MPP(+)) in inhibiting cocaine analog… CONTINUE READING

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