Interaction of cardenolides of the strophanthidin series with functionally important sections of transport Na,K-ATPase

Abstract

On the basis of an analysis of the structure-activity interrelationship of cardiac glycosides and their analogs, four-center model of the binding of the compounds with Na,K-ATPase has been proposed. These centers are represented by the steroid nucleus with a polar group at C-3 and a hydroxy group at C-14, and also by a lactone ring with a double bond. It… (More)
DOI: 10.1007/BF00579769

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