Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI.

@article{Andrews2002InteractionOC,
  title={Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI.},
  author={Robert K Andrews and Katsue Suzuki-Inoue and Yang Shen and David Tulasne and Stephen P. Watson and Michael C. Berndt},
  journal={Blood},
  year={2002},
  volume={99 11},
  pages={4219-21}
}
The platelet collagen receptor, glycoprotein VI (GPVI), and GPIb-IX-V, which binds von Willebrand factor, initiate platelet aggregation at low or high shear stress, respectively. We recently reported that positively charged, membrane-proximal sequences within cytoplasmic domains of GPIbbeta and GPV of GPIb-IX-V bind calmodulin. We now show that GPVI also binds calmodulin as follows-(1) calmodulin coimmunoprecipitated with GPVI from resting platelet lysates using an anti-GPVI IgG, but partially… CONTINUE READING