Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.

@article{Beijersbergen1994InteractionOC,
  title={Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation.},
  author={Roderick L. Beijersbergen and E. Marielle Hijmans and L Zhu and Ren{\'e} Bernards},
  journal={The EMBO journal},
  year={1994},
  volume={13 17},
  pages={
          4080-6
        }
}
The product of the c-myc proto-oncogene, c-Myc, is a sequence-specific DNA binding protein with an N-terminal transactivation domain and a C-terminal DNA binding domain. Several lines of evidence indicate that c-Myc activity is essential for normal cell cycle progression. Since the abundance of c-Myc during the cell cycle is constant, c-Myc's activity may be regulated at a post-translational level. We have shown previously that the N-terminus of c-Myc can form a specific complex with the… CONTINUE READING

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