Interaction of c-Abl and p73α and their collaboration to induce apoptosis

  title={Interaction of c-Abl and p73α and their collaboration to induce apoptosis},
  author={R. Agami and G. Blandino and M. Oren and Y. Shaul},
  • R. Agami, G. Blandino, +1 author Y. Shaul
  • Published 1999
  • Biology
  • Nature
  • c-Abl, a non-receptor tyrosine kinase, is activated by agents that damage DNA. This activation results in either arrest of the cell cycle in phase G1 or apoptotic cell death, both of which are dependent on the kinase activity of c-Abl. p73, a member of the p53 family of tumour-suppressor proteins,, can also induce apoptosis. Here we show that the apoptotic activity of p73α requires the presence of functional, kinase-competent c-Abl. Furthermore, p73 and c-Abl can associate with each other, and… CONTINUE READING
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