Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro.

  title={Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro.},
  author={Wenjian Zhang and Yamini Ramamoorthy and Rachel F. Tyndale and Edward Sellers},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={31 6},
Buprenorphine is a thebaine derivative used in the treatment of heroin and other opiate addictions. In this study, the selective probe reactions for each of the major hepatic cytochromes P450 (P450s) were used to evaluate the effect of buprenorphine and its main metabolite norbuprenorphine on the activity of these P450s. The index reactions used were CYP1A2 (phenacetin O-deethylation), CYP2A6 (coumarin 7-hydroxylation), CYP2C9 (diclofenac 4'-hydroxylation), CYP2C19 (omeprazole 5-hydrxoylation… 

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