Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin

@article{Paschal1989InteractionOB,
  title={Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin},
  author={Bryce M. Paschal and Robert A. Obar and Richard B Vallee},
  journal={Nature},
  year={1989},
  volume={342},
  pages={569-572}
}
TWO main types of microtubule-associated proteins (MAPs) have been identified in neuronal cells. The fibrous MAPs, including MAP2 and tau, serve to organize and regulate the assembly of microtubules. A second distinct class of force-producing MAPs, including kinesin1, dynein2–4 and dynamin5, are involved in micro-tubule-based movement. These proteins are mechanochemical ATPases which seem to be responsible for the bidirectional transport of organelles and perhaps also the movement of… CONTINUE READING

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