Interaction of biodegradable nanoparticles with intestinal cells: the effect of surface hydrophilicity.

@article{Gaumet2010InteractionOB,
  title={Interaction of biodegradable nanoparticles with intestinal cells: the effect of surface hydrophilicity.},
  author={Marie Gaumet and Robert Gurny and Florence Delie},
  journal={International journal of pharmaceutics},
  year={2010},
  volume={390 1},
  pages={45-52}
}
The aim of the present work was to study the influence of surface hydrophilicity of biodegradable polymeric nanoparticles on cellular uptake by Caco-2 cells. Poly(D,L-lactide-co-glycolide acid) particles loaded with a fluorescent dye, 3,3'-dioctadecyloxacarbo-cyanine perchlorate (DiO), were prepared by the emulsion-evaporation process. Three batches of particles with narrow size distribution (100, 300 and 1000 nm) were produced using selective centrifugation. One set of particles was coated by… CONTINUE READING

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