Interaction of beta-carbolines with central dopaminergic transmission in mice: structure-activity relationships.

@article{Pimpinella1995InteractionOB,
  title={Interaction of beta-carbolines with central dopaminergic transmission in mice: structure-activity relationships.},
  author={Giuseppe Pimpinella and Maura Palmery},
  journal={Neuroscience letters},
  year={1995},
  volume={189 2},
  pages={121-4}
}
Although several beta-carboline alkaloids display hallucinogenic properties in humans, their mechanism of action remains unclear. To ascertain their influence on central dopaminergic transmission, in this study we investigated the facilitating effect of low doses of various beta-carbolines on L-DOPA (250 mg/kg)-induced stereotypy in mice. Harmaline (0.075, 0.15 and 0.35 mg/kg) and harmine (0.15, 0.35 and 0.75 mg/kg) powerfully enhanced the degree of stereotypy, whereas 6-methoxy-harmalan, 6… CONTINUE READING