Interaction of barbiturate analogs with the Torpedo californica nicotinic acetylcholine receptor ion channel.

@article{Arias2001InteractionOB,
  title={Interaction of barbiturate analogs with the Torpedo californica nicotinic acetylcholine receptor ion channel.},
  author={Hugo Arias and Elizabeth A. McCardy and Martin P. Gallagher and Michael Paul Blanton},
  journal={Molecular pharmacology},
  year={2001},
  volume={60 3},
  pages={497-506}
}
Barbiturate-induced anesthesia is a complex mechanism that probably involves several ligand-gated ion channel superfamilies. One of these superfamilies includes the archetypical nicotinic acetylcholine receptor (nAChR), in which barbiturates act as noncompetitive antagonists. In this regard, we used the Torpedo californica nAChR and a series of barbiturate analogs to characterize the barbiturate binding site(s) on this superfamily member. [(14)C]Amobarbital binds to one high-affinity (K(d) = 3… CONTINUE READING