Interaction of azimilide with neurohumoral and channel receptors.

@article{Brooks2001InteractionOA,
  title={Interaction of azimilide with neurohumoral and channel receptors.},
  author={Robert R. Brooks and Schwe Fang Pong and Nicholas J. Izzo and Thomas John Moorehead and Murali Gopalakrishnan and David J. Triggle},
  journal={Biochemical pharmacology},
  year={2001},
  volume={62 7},
  pages={
          883-92
        }
}
Effects of azimilide on the muscarinic acetylcholine receptor-operated K+ current and experimental atrial fibrillation in guinea-pig hearts.
TLDR
In isolated hearts, perfusion of CCh shortened the duration of the monophasic action potential (MAP) and effective refractory period (ERP) of the left atrium and lowered the atrial fibrillation threshold (AFT).
Influence of ketanserin on the effects of methylenedioxymethamphetamine on body temperature in the mouse.
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Ketanserin modulates the hyperthermic actions of MDMA in mice and is consistent with α1 -adrenoceptor antagonism, although there is no clear evidence from this study that 5HT2-receptors mediate thehyperthermic response to MDMA.
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Azimilide attenuated I(NCX) in the presence of trypsin in the patch pipette, indicating that azimilide is aTrypsin-insensitive NCX inhibitor.
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New mechanisms and therapeutic potential of curcumin for colorectal cancer.
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An update of the bioavailability and pharmacokinetics of curcumin is provided and the recently identified molecular pathways responsible of its anticancer potential in CRC are described.
Tail Current and Modulate Insulin Secretion
  • 2005

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