Interaction of asparagine and EGF in the regulation of ornithine decarboxylase in IEC-6 cells.

@article{Ray1999InteractionOA,
  title={Interaction of asparagine and EGF in the regulation of ornithine decarboxylase in IEC-6 cells.},
  author={Ramesh Ray and Mary Jane Viar and Tarun B. Patel and Leonard R. Johnson},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1999},
  volume={276 3},
  pages={G773-G780}
}
Our laboratory has shown that asparagine (ASN) stimulates both ornithine decarboxylase (ODC) activity and gene expression in an intestinal epithelial cell line (IEC-6). The effect of ASN is specific, and other A- and N-system amino acids are almost as effective as ASN when added alone. In the present study, epidermal growth factor (EGF) was unable to increase ODC activity in cells maintained in a salt-glucose solution (Earle's balanced salt solution). However, the addition of ASN (10 mM) in the… CONTINUE READING