Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors.

@article{Wu1997InteractionOA,
  title={Interaction of arrestins with intracellular domains of muscarinic and alpha2-adrenergic receptors.},
  author={Gengshu Wu and Jason G. Krupnick and Jeffrey L. Benovic and Stephen M. Lanier},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 28},
  pages={
          17836-42
        }
}
The intracellular domains of G-protein-coupled receptors provide sites for interaction with key proteins involved in signal initiation and termination. As an initial approach to identify proteins interacting with these receptors and the receptor motifs required for such interactions, we used intracellular subdomains of G-protein-coupled receptors as probes to screen brain cytosol proteins. Peptides from the third intracellular loop (i3) of the M2-muscarinic receptor (MR) (His208-Arg387), M3-MR… CONTINUE READING

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