Interaction of anticancer drug mitoxantrone with DNA analyzed by electrochemical and spectroscopic methods.

@article{Li2005InteractionOA,
  title={Interaction of anticancer drug mitoxantrone with DNA analyzed by electrochemical and spectroscopic methods.},
  author={Nan Li and Ying Ma and Cheng Yang and Liping Guo and Xiurong Yang},
  journal={Biophysical chemistry},
  year={2005},
  volume={116 3},
  pages={199-205}
}
Cyclic voltammetry coupled with different spectroscopic (UV/Vis, fluorescence and Raman) techniques were used to study the interaction of mitoxantrone (MTX), an antitumor drug, with calf thymus DNA in acetate buffer solutions (pH 4.5). The interaction of MTX with DNA could result a considerable decrease in the MTX peak currents and a hypochromic and bathochromic shift in the maximum adsorption bands of MTX as well as the emission quenching in the MTX fluorescence spectra. The variations in the… CONTINUE READING

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