Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies

@article{MartnezValbuena2018InteractionOA,
  title={Interaction of amyloidogenic proteins in pancreatic $\beta$ cells from subjects with synucleinopathies},
  author={Ivan Mart{\'i}nez-Valbuena and Irene Amat-Villegas and Rafael Valenti-Azcarate and Mar Carmona-Abell{\'a}n and Irene Marcilla and Mar{\'i}a Teresa Tu{\~n}{\'o}n and M. R. Luquin},
  journal={Acta Neuropathologica},
  year={2018},
  volume={135},
  pages={877-886}
}
Parkinson’s disease patients experience a wide range of non-motor symptoms that may be provoked by deposits of phosphorylated α-synuclein in the peripheral nervous system. Pre-existing diabetes mellitus might be a risk factor for developing Parkinson’s disease, and indeed, nearly 60% of Parkinson’s disease patients are insulin resistant. Thus, we have investigated whether phosphorylated α-synuclein is deposited in pancreatic tissue of subjects with synucleinopathies. We studied pancreatic… 
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