Interaction of amphiphilic cyclic peptide with double and triple stranded DNA.

Abstract

It was found that Gramicidin S (GS) with intramolecular antiparallel beta-sheet structure could bind to and thermally stabilize double and triple stranded DNA. UV melting study revealed that GS stabilized mixed sequence dsDNA in the presence of Mg2+ (deltaTm = +6.0) but it stabilized dsDNA with homosequence only in the absence of Mg2+. It should be pointed… (More)

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Cite this paper

@article{Yokoyama1999InteractionOA, title={Interaction of amphiphilic cyclic peptide with double and triple stranded DNA.}, author={K Yokoyama and Takeshi Kubo and Masato Fujii}, journal={Nucleic acids symposium series}, year={1999}, volume={42}, pages={169-70} }