Corpus ID: 25356961

Interaction of aminoglycoside antibiotics and calcium channel blockers at the neuromuscular junctions.

@article{Paradelis1988InteractionOA,
  title={Interaction of aminoglycoside antibiotics and calcium channel blockers at the neuromuscular junctions.},
  author={A. G. Paradelis and C J Triantaphyllidis and M Mironidou and L G Crassaris and D N Karachalios and Maria Giala},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1988},
  volume={10 11},
  pages={
          687-90
        }
}
Aminoglycoside antibiotics (mmol.l-1) gentamicin (0.74), streptomycin (1.02), netilmicin (1.24), amikacin (2.23), sisomicin (2.74), dactimicin (2.75), kanamycin (3.43), kanendomycin (3.45), tobramycin (3.53) and dibekacin (4.35) produce a complete neuromuscular blockade at the isolated phrenic nerve-hemidiaphragm preparation of the rat, which is only reversed by calcium chloride. On the other hand, verapamil (2.04 mmol.l-1), a calcium channel blocker, also produces a complete neuromuscular… Expand
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