Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson’s disease: a case for the selective vulnerability of the substantia nigra

@article{Galvin2006InteractionOA,
  title={Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson’s disease: a case for the selective vulnerability of the substantia nigra},
  author={James E. Galvin},
  journal={Acta Neuropathologica},
  year={2006},
  volume={112},
  pages={115-126}
}
Parkinson’s disease (PD) is the most common movement disorder. Major disease symptoms are due to the loss of dopaminergic (DA) neurons in substantia nigra (SN). The pathologic hallmark of PD is Lewy bodies (LBs) in the SN and the major protein in LBs is alpha-synuclein (AS). A plethora of evidence points towards the culpability of AS in the pathogenesis of PD including: (1) linkage of AS mutations to familial forms of PD, (2) triplication of the AS locus causing PD, and (3) overexpression of AS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 112 references

DOPAL, the MAO metabolite of dopamine, triggers aggregation of -synuclein in vitro: mechanism in PD pathogenesis (manuscript under review

WJ Burke, MW Franko, HD Chung, VB Kumar, JE Galvin
2006
View 9 Excerpts
Highly Influenced

3,4-Dihydroxyphenylacetaldehyde: endogenous neurotoxin in Parkinson’s disease

BS Kristal, WJ Burke, W Li, AM Brown
Free Radic Biol Med • 2001
View 14 Excerpts
Highly Influenced

Dopamine MAO metabolite and hydrogen peroxide generate hydroxyl radical

SW Li, T-S Lin, WJ Burke
Mol Brain Res 93:1–7 • 2001
View 12 Excerpts
Highly Influenced

Catecholamine metabolism: basic aspects and clinical significance.

Pharmacological reviews • 1985
View 14 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…